Physical Interaction between MYCN Oncogene and Polycomb Repressive Complex 2 (PRC2) in Neuroblastoma: FUNCTIONAL AND THERAPEUTIC IMPLICATIONS

CLU (clusterin) is a tumor suppressor gene that we have previously shown to be negatively modulated by the MYCN proto-oncogene, but the mechanism of repression was unclear. Here, we show that MYCN inhibits the expression of CLU by direct interaction with the non-canonical E box sequence CACGCG in th...

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Detalhes bibliográficos
Main Authors: Corvetta, Daisy, Chayka, Olesya, Gherardi, Samuele, D'Acunto, Cosimo W., Cantilena, Sandra, Valli, Emanuele, Piotrowska, Izabela, Perini, Giovanni, Sala, Arturo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605651/
https://ncbi.nlm.nih.gov/pubmed/23362253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.454280
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