Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population.

We characterized the basis for the follicular lymphoproliferation in transgenic mice bearing a Bcl-2-immunoglobulin (Bcl-2-Ig) minigene representing the t(14;18) of human follicular lymphoma. Discriminatory S1 nuclease protection assays revealed that the Bcl-2-Ig transgene was overexpressed relative...

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Publicat a:Mol Cell Biol
Autors principals: McDonnell, T J, Nunez, G, Platt, F M, Hockenberry, D, London, L, McKearn, J P, Korsmeyer, S J
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 1990
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360535/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2183011/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.10.5.1901
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