The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors.

Antzeko izenburuak

• Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells.
  nork: Lee, C H, et al.
  Argitaratua: (1993)
• The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.
  nork: Skolnik, E Y, et al.
  Argitaratua: (1993)
• The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels.
  nork: Chou, M M, et al.
  Argitaratua: (1992)
• The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment.
  nork: Meisenhelder, J, et al.
  Argitaratua: (1992)
• Studies of novel interactions between Nck and VAV SH3 domains
  nork: Pauker, Maor H, et al.
  Argitaratua: (2011)