The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors.

Documenti analoghi

• Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells.
  di: Lee, C H, et al.
  Pubblicazione: (1993)
• The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.
  di: Skolnik, E Y, et al.
  Pubblicazione: (1993)
• The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels.
  di: Chou, M M, et al.
  Pubblicazione: (1992)
• The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment.
  di: Meisenhelder, J, et al.
  Pubblicazione: (1992)
• SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma.
  di: Rotin, D, et al.
  Pubblicazione: (1992)