β-cell metabolic alterations under chronic nutrient overload in rat and human islets

The aim of this study was to assess multifactorial β-cell responses to metabolic perturbations in primary rat and human islets. Treatment of dispersed rat islet cells with elevated glucose and free fatty acids (FFAs, oleate:palmitate = 1:1 v/v) resulted in increases in the size and the number of lip...

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Detalhes bibliográficos
Main Authors: Vernier, Stephanie, Chiu, Angela, Schober, Joseph, Weber, Theresa, Nguyen, Phuong, Luer, Mark, McPherson, Timothy, Wanda, Paul E., Marshall, Connie A., Rohatgi, Nidhi, McDaniel, Michael L., Greenberg, Andrew S., Kwon, Guim
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605166/
https://ncbi.nlm.nih.gov/pubmed/23247575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/isl.22720
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