Glycogen Synthase Kinase-3 and Mammalian Target of Rapamycin Pathways Contribute to DNA Synthesis, Cell Cycle Progression, and Proliferation in Human Islets

OBJECTIVE—Our previous studies demonstrated that nutrient regulation of mammalian target of rapamycin (mTOR) signaling promotes regenerative processes in rodent islets but rarely in human islets. Our objective was to extend these findings by using therapeutic agents to determine whether the regulati...

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Detalhes bibliográficos
Main Authors: Liu, Hui, Remedi, Maria S., Pappan, Kirk L., Kwon, Guim, Rohatgi, Nidhi, Marshall, Connie A., McDaniel, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2009
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646065/
https://ncbi.nlm.nih.gov/pubmed/19073772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1208
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