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Impact of misspecifying the distribution of a prognostic factor on power and sample size for testing treatment interactions in clinical trials
BACKGROUND: Interaction in clinical trials presents challenges for design and appropriate sample size estimation. Here we considered interaction between treatment assignment and a dichotomous prognostic factor with a continuous outcome. Our objectives were to describe differences in power and sample...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3605155/ https://ncbi.nlm.nih.gov/pubmed/23414513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2288-13-21 |
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