Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained

Genome-wide association studies (GWAS) have identified ∼100 loci associated with blood lipid levels, but much of the trait heritability remains unexplained, and at most loci the identities of the trait-influencing variants remain unknown. We conducted a trans-ethnic fine-mapping study at 18, 22, and...

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Main Authors: Wu, Ying, Waite, Lindsay L., Jackson, Anne U., Sheu, Wayne H-H., Buyske, Steven, Absher, Devin, Arnett, Donna K., Boerwinkle, Eric, Bonnycastle, Lori L., Carty, Cara L., Cheng, Iona, Cochran, Barbara, Croteau-Chonka, Damien C., Dumitrescu, Logan, Eaton, Charles B., Franceschini, Nora, Guo, Xiuqing, Henderson, Brian E., Hindorff, Lucia A., Kim, Eric, Kinnunen, Leena, Komulainen, Pirjo, Lee, Wen-Jane, Le Marchand, Loic, Lin, Yi, Lindström, Jaana, Lingaas-Holmen, Oddgeir, Mitchell, Sabrina L., Narisu, Narisu, Robinson, Jennifer G., Schumacher, Fred, Stančáková, Alena, Sundvall, Jouko, Sung, Yun-Ju, Swift, Amy J., Wang, Wen-Chang, Wilkens, Lynne, Wilsgaard, Tom, Young, Alicia M., Adair, Linda S., Ballantyne, Christie M., Bůžková, Petra, Chakravarti, Aravinda, Collins, Francis S., Duggan, David, Feranil, Alan B., Ho, Low-Tone, Hung, Yi-Jen, Hunt, Steven C., Hveem, Kristian, Juang, Jyh-Ming J., Kesäniemi, Antero Y., Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A., Lee, I-Te, Leppert, Mark F., Matise, Tara C., Moilanen, Leena, Njølstad, Inger, Peters, Ulrike, Quertermous, Thomas, Rauramaa, Rainer, Rotter, Jerome I., Saramies, Jouko, Tuomilehto, Jaakko, Uusitupa, Matti, Wang, Tzung-Dau, Boehnke, Michael, Haiman, Christopher A., Chen, Yii-Der I., Kooperberg, Charles, Assimes, Themistocles L., Crawford, Dana C., Hsiung, Chao A., North, Kari E., Mohlke, Karen L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2013
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605054/
https://ncbi.nlm.nih.gov/pubmed/23555291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003379
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