A mammalian cell line deficient in activity of the DNA repair enzyme 5-hydroxymethyluracil-DNA glycosylase is resistant to the toxic effects of the thymidine analog 5-hydroxymethyl-2'-deoxyuridine.

We isolated a mutant mammalian cell line lacking activity for the DNA repair enzyme 5-hydroxymethyluracil-DNA glycosylase (HmUra-DNA glycosylase). The mutant was isolated through its resistance to the thymidine analog 5-hydroxymethyl-2'-deoxyuridine (HmdUrd). The mutant incorporates HmdUrd into...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Boorstein, R J, Chiu, L N, Teebor, G W
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1992
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC360491/
https://ncbi.nlm.nih.gov/pubmed/1448084
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk