A mammalian cell line deficient in activity of the DNA repair enzyme 5-hydroxymethyluracil-DNA glycosylase is resistant to the toxic effects of the thymidine analog 5-hydroxymethyl-2'-deoxyuridine.

Lignende værker

• Phylogenetic evidence of a role for 5-hydroxymethyluracil-DNA glycosylase in the maintenance of 5-methylcytosine in DNA.
  af: Boorstein, R J, et al.
  Udgivet: (1989)
• Hydroxymethyluracil DNA glycosylase in mammalian cells.
  af: Hollstein, M C, et al.
  Udgivet: (1984)
• Site directed substitution of 5-hydroxymethyluracil for thymine in replicating phi X-174am3 DNA via synthesis of 5-hydroxymethyl-2'-deoxyuridine-5'-triphosphate.
  af: Levy, D D, et al.
  Udgivet: (1991)
• Ionizing radiation and tritium transmutation both cause formation of 5-hydroxymethyl-2'-deoxyuridine in cellular DNA.
  af: Teebor, G W, et al.
  Udgivet: (1984)
• Evaluating the Genotoxic and Cytotoxic Effects of Thymidine Analogs, 5-Ethynyl-2′-Deoxyuridine and 5-Bromo-2′-Deoxyurdine to Mammalian Cells
  af: Haskins, Jeremy S., et al.
  Udgivet: (2020)