A mammalian cell line deficient in activity of the DNA repair enzyme 5-hydroxymethyluracil-DNA glycosylase is resistant to the toxic effects of the thymidine analog 5-hydroxymethyl-2'-deoxyuridine.

We isolated a mutant mammalian cell line lacking activity for the DNA repair enzyme 5-hydroxymethyluracil-DNA glycosylase (HmUra-DNA glycosylase). The mutant was isolated through its resistance to the thymidine analog 5-hydroxymethyl-2'-deoxyuridine (HmdUrd). The mutant incorporates HmdUrd into DNA...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Boorstein, R J, Chiu, L N, Teebor, G W
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360491/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1448084/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.12.5536-5540.1992
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