Unstable amplification of two extrachromosomal elements in alpha-difluoromethylornithine-resistant Leishmania donovani.

We describe the first example of unstable gene amplification consisting of linear extrachromosomal DNAs in drug-resistant eukaryotic cells. alpha-Difluoromethylornithine (DFMO)-resistant Leishmania donovani with an amplified ornithine decarboxylase (ODC) gene copy number contained two new extrachrom...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Principais autores:	Hanson, S, Beverley, S M, Wagner, W, Ullman, B
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis 1992
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360487/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1448081/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.12.5499-5507.1992
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