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Slicing-Independent RISC Activation Requires the Argonaute PAZ Domain

Small RNAs regulate genetic networks through a ribonucleo-protein complex called the RNA-induced silencing complex (RISC), which, in mammals, contains at its center one of four Argonaute proteins (Ago1–Ago4) (reviewed in [1–4]). A key regulatory event in the RNA interference (RNAi) and microRNA (miR...

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Bibliographic Details
Main Authors: Gu, Shuo, Jin, Lan, Huang, Yong, Zhang, Feijie, Kay, Mark A.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3604743/
https://ncbi.nlm.nih.gov/pubmed/22795694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2012.06.040
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