A Wt1-controlled chromatin switching mechanism underpins tissue-specific Wnt4 activation and repression

Wt1 regulates the epithelial-mesenchymal transition (EMT) in the epicardium and the reverse process (MET) in kidney mesenchyme. The mechanisms underlying these reciprocal functions are unknown. Here, we show in both embryos and cultured cells that Wt1 regulates Wnt4 expression dichotomously. In kidn...

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Main Authors: Essafi, Abdelkader, Webb, Anna, Berry, Rachel L., Slight, Joan, Burn, Sally F., Spraggon, Lee, Velecela, Victor, Martinez-Estrada, Ofelia M., Wiltshire, John H., Roberts, Stefan G.E., Brownstein, David, Davies, Jamie A., Hastie, Nicholas D., Hohenstein, Peter
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3604688/
https://ncbi.nlm.nih.gov/pubmed/21871842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2011.07.014
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