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Free Fatty Acid Induces Endoplasmic Reticulum Stress and Apoptosis of β-cells by Ca(2+)/Calpain-2 Pathways
Dysfunction of β-cells is a major characteristic in the pathogenesis of type 2 diabetes mellitus (T2DM). The combination of obesity and T2DM is associated with elevated plasma free fatty acids (FFAs). However, molecular mechanisms linking FFAs to β-cell dysfunction remain poorly understood. In the p...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3604010/ https://ncbi.nlm.nih.gov/pubmed/23527285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059921 |
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