The Mucosal Adjuvant Cholera Toxin B Instructs Non-Mucosal Dendritic Cells to Promote IgA Production Via Retinoic Acid and TGF-β

It is currently unknown how mucosal adjuvants cause induction of secretory immunoglobulin A (IgA), and how T cell-dependent (TD) or -independent (TI) pathways might be involved. Mucosal dendritic cells (DCs) are the primary antigen presenting cells driving TI IgA synthesis, by producing a proliferat...

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Autors principals: Gloudemans, Anouk K., Plantinga, Maud, Guilliams, Martin, Willart, Monique A., Ozir-Fazalalikhan, Arifa, van der Ham, Alwin, Boon, Louis, Harris, Nicola L., Hammad, Hamida, Hoogsteden, Henk C., Yazdanbakhsh, Maria, Hendriks, Rudi W., Lambrecht, Bart N., Smits, Hermelijn H.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603891/
https://ncbi.nlm.nih.gov/pubmed/23527272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059822
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