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Sequences in the human c-myc P2 promoter affect the elongation and premature termination of transcripts initiated from the upstream P1 promoter.

A conditional block to transcription elongation provides one mechanism for controlling the steady-state levels of c-myc RNA in mammalian cells. Although prematurely terminated c-myc RNAs are not detectable in mammalian cells, truncated c-myc RNAs with 3' ends that map near the end of the first exon...

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Vydáno v:Mol Cell Biol
Hlavní autoři: Meulia, T, Krumm, A, Spencer, C, Groudine, M
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 1992
Témata:
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360386/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1406649/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.10.4590-4600.1992
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