Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells

Although the combination of herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) with ganciclovir (GCV) has been shown as a promising suicide gene treatment strategy for glioma, the almost immunodepressive dose of GCV required for its adequate in vivo efficacy has hampered its further clinical...

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Bibliographic Details
Main Authors: Li, Lei-qing, Shen, Fang, Xu, Xiao-yan, Zhang, Hong, Yang, Xiao-feng, Liu, Wei-guo
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603674/
https://ncbi.nlm.nih.gov/pubmed/23533367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/951343
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