Modeling Interindividual Variability in Physiologically Based Pharmacokinetics and Its Link to Mechanistic Covariate Modeling

Covariate modeling is a key step in the analysis of clinical data and is essential for establishing dosing recommendations for specific populations, e.g., in obese individuals and children. So far, no systematic approach exists to leverage the knowledge inherent in physiologically based pharmacokine...

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Bibliografski detalji
Glavni autori: Huisinga, W, Solms, A, Fronton, L, Pilari, S
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603474/
https://ncbi.nlm.nih.gov/pubmed/23835884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2012.3
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