Modeling Interindividual Variability in Physiologically Based Pharmacokinetics and Its Link to Mechanistic Covariate Modeling

Covariate modeling is a key step in the analysis of clinical data and is essential for establishing dosing recommendations for specific populations, e.g., in obese individuals and children. So far, no systematic approach exists to leverage the knowledge inherent in physiologically based pharmacokine...

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Detalhes bibliográficos
Main Authors: Huisinga, W, Solms, A, Fronton, L, Pilari, S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603474/
https://ncbi.nlm.nih.gov/pubmed/23835884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2012.3
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