Effective RNAi-mediated β2-microglobulin loss of function by transgenesis in Xenopus laevis

To impair MHC class I (class I) function in vivo in the amphibian Xenopus, we developed an effective reverse genetic loss of function approach by combining I-SceI meganuclease-mediated transgenesis with RNAi technology. We generated transgenic outbred X. laevis and isogenetic laevis/gilli cloned lin...

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Sonraí Bibleagrafaíochta
Main Authors: Nedelkovska, Hristina, Edholm, Eva-Stina, Haynes, Nikesha, Robert, Jacques
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Company of Biologists 2013
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603415/
https://ncbi.nlm.nih.gov/pubmed/23519478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.20133483
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