Differing clinical impact of BRCA1 and BRCA2 mutations in serous ovarian cancer

A key function of BRCA1 and BRCA2 is the participation in dsDNAbreak repair via homologous recombination. BRCA1 and BRCA2 mutations, which occur in most hereditary ovarian cancers (OCs) and approximately 10% of all OC cases, are associated with defects in homologous recombination and genomic instabi...

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Bibliographic Details
Main Authors: Liu, Guoyan, Yang, Da, Sun, Yan, Shmulevich, Ilya, Xue, Fengxia, Sood, Anil K, Zhang, Wei
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603383/
https://ncbi.nlm.nih.gov/pubmed/23057551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs.12.137
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