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Differing clinical impact of BRCA1 and BRCA2 mutations in serous ovarian cancer
A key function of BRCA1 and BRCA2 is the participation in dsDNAbreak repair via homologous recombination. BRCA1 and BRCA2 mutations, which occur in most hereditary ovarian cancers (OCs) and approximately 10% of all OC cases, are associated with defects in homologous recombination and genomic instabi...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3603383/ https://ncbi.nlm.nih.gov/pubmed/23057551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs.12.137 |
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