Intrathecal cannabilactone CB(2)R agonist, AM1710, controls pathological pain and restores basal cytokine levels

Spinal glial and proinflammatory cytokine actions are strongly implicated in pathological pain. Spinal administration of the anti-inflammatory cytokine, interleukin-10 (IL-10) abolishes pathological pain and suppresses proinflammatory interleukin-1β (IL-1β) and tumor necrosis factor alpha (TNF-α). D...

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Main Authors: Wilkerson, Jenny L., Gentry, Katherine R., Dengler, Ellen C., Wallace, James A., Kerwin, Audra A., Armijo, Leisha M., Kuhn, Megan N., Thakur, Ganesh A., Makriyannis, Alexandros, Milligan, Erin D.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603341/
https://ncbi.nlm.nih.gov/pubmed/22425445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2012.02.015
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