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Impact of Proton Pump Inhibitor Therapy on the Efficacy of Clopidogrel in the CAPRIE and CREDO Trials
BACKGROUND: Proton pump inhibitors (PPIs) may interfere with the metabolic activation of clopidogrel via inhibition of cytochrome P450 2C19, but the clinical implications remain unclear. METHODS AND RESULTS: The impact of PPI use on the 1‐year primary end point (ischemic stroke, myocardial infarctio...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Blackwell Publishing Ltd
2013
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3603228/ https://ncbi.nlm.nih.gov/pubmed/23525436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.112.004564 |
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