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Impact of proton pump inhibitors on efficacy of clopidogrel: Review of evidence
Clopidogrel is a prodrug which requires cytochrome P450 2C19 (CYP 2C19) enzyme for its conversion to an active thiol metabolite. Proton pump inhibitors (PPIs) inhibits enzyme CYP 2C19 interfering with the conversion of clopidogrel into its active metabolite. Studies document the possible interaction...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Medknow Publications
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3081459/ https://ncbi.nlm.nih.gov/pubmed/21572655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0253-7613.77360 |
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