Enhanced Vascular Chymase-Dependent Conversion of Endothelin in the Diabetic Kidney

BACKGROUND: Diabetic nephropathy (DN) is associated with enhanced renal, plasma, and urinary endothelin (ET)-1 levels. Chymase cleaves Big ET-1 (1-38) to ET-1 (1-31), which is further cleaved by neutral endopeptidase to ET-1 (1-21). The current study tested the hypothesis that afferent arterioles (A...

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Main Authors: Harrison-Bernard, Lisa M., de Garavilla, Lawrence, Bivona, Benjamin J.
Format: Artigo
Sprog:Inglês
Udgivet: the Academic Division of Ochsner Clinic Foundation 2013
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603188/
https://ncbi.nlm.nih.gov/pubmed/23532714
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