Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1

The PHD finger protein 1 (PHF1) is essential in epigenetic regulation and genome maintenance. Here, we demonstrate that the Tudor domain of human PHF1 binds to histone H3 trimethylated at Lys36 (H3K36me3). We report a 1.9 Å resolution crystal structure of the Tudor domain in complex with H3K36me3 an...

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Autori principali: Musselman, Catherine A., Avvakumov, Nikita, Watanabe, Reiko, Abraham, Christopher G., Lalonde, Marie-Eve, Hong, Zehui, Allen, Christopher, Roy, Siddhartha, Nuñez, James K., Nickoloff, Jac, Kulesza, Caroline A., Yasui, Akira, Côté, Jacques, Kutateladze, Tatiana G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603146/
https://ncbi.nlm.nih.gov/pubmed/23142980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2435
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