Association between VEGF splice isoforms and progression free survival in metastatic colorectal cancer patients treated with bevacizumab

PURPOSE: Bevacizumab improves survival for metastatic colorectal cancer patients with chemotherapy, but no proven predictive markers exist. The VEGF-A splice form, VEGF(165)b, anti-angiogenic in animal models, binds bevacizumab. We tested the hypothesis that prolonged progression-free survival (PFS)...

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Detalhes bibliográficos
Main Authors: Bates, David O., Catalano, Paul J., Symonds, Kirsty E, Varey, Alex H.R., Ramani, Pramila, O’Dwyer, Peter J., Giantonio, Bruce J., Meropol, Neal J., Benson, Al Bowen, Harper, Steven J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602975/
https://ncbi.nlm.nih.gov/pubmed/23104894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2223
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