Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage

Hypertension and renal damage in Dahl SS rats are associated with increased infiltrating immune cells in the kidney. To examine the role of infiltrating immune cells in this disease process, a zinc finger nuclease targeting bases 672–706 of recombination-activating gene 1 (Rag1) was injected into th...

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Main Authors: Mattson, David L., Lund, Hayley, Guo, Chuanling, Rudemiller, Nathan, Geurts, Aron M., Jacob, Howard
Format: Artigo
Language:Inglês
Published: American Physiological Society 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602820/
https://ncbi.nlm.nih.gov/pubmed/23364523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00304.2012
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