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Spontaneous and evoked contractions are regulated by PKC-mediated signaling in detrusor smooth muscle: involvement of BK channels

Protein kinase C (PKC) and large conductance Ca(2+)-activated potassium channels (BK) are downregulated in the detrusor smooth muscle (DSM) in partial bladder outlet obstruction (PBOO). DSM from these bladders display increased spontaneous activity. This study examines the involvement of PKC in the...

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Hlavní autoři: Hypolite, Joseph A., Lei, Qi, Chang, Shaohua, Zderic, Stephen A., Butler, Stephan, Wein, Alan J., Malykhina, Anna P., Chacko, Samuel
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602715/
https://ncbi.nlm.nih.gov/pubmed/23269650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00639.2011
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