Hemimethylation and hypersensitivity are early events in transcriptional reactivation of human inactive X-linked genes in a hamster x human somatic cell hybrid.

Reactivation of the hypoxanthine phosphoribosyltransferase (HPRT) gene on an inactive human X chromosome in a somatic cell hybrid was analyzed following exposure to 5-aza-2'-deoxycytidine. Hemimethylation and chromatin hypersensitivity in the 5' CpG island appeared by 6 h after exposure an...

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Hauptverfasser: Sasaki, T, Hansen, R S, Gartler, S M
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1992
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC360251/
https://ncbi.nlm.nih.gov/pubmed/1380647
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