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P-glycoprotein is fully active after multiple tryptophan substitutions
P-glycoprotein (Pgp) is an important contributor to multidrug resistance of cancer. Pgp contains eleven native tryptophans (Trps) that are highly conserved among orthologs. We replaced each Trp by a conservative substitution to determine which Trps are important for function. Individual Trp mutants...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3602414/ https://ncbi.nlm.nih.gov/pubmed/23261390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2012.12.005 |
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