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The Extent of Synaptic Stripping of Motoneurons after Axotomy Is Not Correlated to Activation of Surrounding Glia or Downregulation of Postsynaptic Adhesion Molecules

Synapse elimination in the adult central nervous system can be modelled by axotomy of spinal motoneurons which triggers removal of synapses from the cell surface of lesioned motoneurons by processes that remain elusive. Proposed candidate mechanisms are removal of synapses by reactive microglia and...

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Autors principals: Berg, Alexander, Zelano, Johan, Thams, Sebastian, Cullheim, Staffan
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602371/
https://ncbi.nlm.nih.gov/pubmed/23527240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059647
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