An attenuated Lassa vaccine in SIV-infected rhesus macaques does not persist or cause arenavirus disease but does elicit Lassa virus-specific immunity

BACKGROUND: Lassa hemorrhagic fever (LHF) is a rodent-borne viral disease that can be fatal for human beings. In this study, an attenuated Lassa vaccine candidate, ML29, was tested in SIV-infected rhesus macaques for its ability to elicit immune responses without instigating signs pathognomonic for...

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Main Authors: Zapata, Juan C, Poonia, Bhawna, Bryant, Joseph, Davis, Harry, Ateh, Eugene, George, Lanea, Crasta, Oswald, Zhang, Yan, Slezak, Tom, Jaing, Crystal, Pauza, C David, Goicochea, Marco, Moshkoff, Dmitry, Lukashevich, Igor S, Salvato, Maria S
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602176/
https://ncbi.nlm.nih.gov/pubmed/23402317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-10-52
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