Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression.

The wild-type (wt) p53 protein has transcriptional activation functions which may be linked to its tumor suppressor activity. Many mutant p53 proteins expressed in cancers have lost the ability to function as transcriptional activators and furthermore may inhibit wt p53 function. To study the mechan...

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Bibliografische gegevens

Gepubliceerd in:	Mol Cell Biol
Hoofdauteurs:	Unger, T, Mietz, J A, Scheffner, M, Yee, C L, Howley, P M
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Taylor & Francis 1993
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360207/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8355677/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.9.5186-5194.1993
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