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The region of the HPV E7 oncoprotein homologous to adenovirus E1a and Sv40 large T antigen contains separate domains for Rb binding and casein kinase II phosphorylation.

Some genital human papillomavirus (HPV) types, such as 16 and 18, are highly associated with malignant cervical tumors while others, such as HPV 6, are only rarely found in these malignancies. The E7 oncoproteins of HPV 6, 16 and 18 each have a 17 amino acid region with striking homology to adenovir...

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Udgivet i:EMBO J
Principais autores: Barbosa, M S, Edmonds, C, Fisher, C, Schiller, J T, Lowy, D R, Vousden, K H
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC551641/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2153075/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1990.tb08091.x
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