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Conformational analysis and parallel QM/MM X-ray refinement of protein bound anti-Alzheimer drug donepezil

The recognition and association of donepezil with acetylcholinesterase (AChE) has been extensively studied in the past several decades because of the former’s use as a palliative treatment for mild Alzheimer disease. Herein we examine the conformational properties of donepezil and we re-examine the...

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Autors principals: Fu, Zheng, Li, Xue, Miao, Yipu, Merz, Kenneth M.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601759/
https://ncbi.nlm.nih.gov/pubmed/23526889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct300957x
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