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Assigning the protonation states of the key aspartates in β-Secretase using QM/MM X-ray structure refinement
β-Secretase, a.k.a. β-APP cleaving enzyme (BACE), is an aspartyl protease that has been implicated as a key target in the pathogenesis of Alzheimer’s disease (AD). The identification of the protonation states of the key aspartates in β-secretase is of great interest both in understanding the reactio...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2600719/ https://ncbi.nlm.nih.gov/pubmed/19079786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct0600060 |
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