Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy

The tumour microenvironment thwarts conventional immunotherapy through multiple immunologic mechanisms, such as the secretion of the transforming growth factor-β (TGF-β), which stunts local tumour immune responses. Therefore, high doses of interleukin-2 (IL-2), a conventional cytokine for metastatic...

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Détails bibliographiques
Auteurs principaux: Park, Jason, Wrzesinski, Stephen H., Stern, Eric, Look, Michael, Criscione, Jason, Ragheb, Ragy, Jay, Steven M., Demento, Stacey L., Agawu, Atu, Limon, Paula Licona, Ferrandino, Anthony F., Gonzalez, David, Habermann, Ann, Flavell, Richard A., Fahmy, Tarek M.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601683/
https://ncbi.nlm.nih.gov/pubmed/22797827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmat3355
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