Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy

The tumour microenvironment thwarts conventional immunotherapy through multiple immunologic mechanisms, such as the secretion of the transforming growth factor-β (TGF-β), which stunts local tumour immune responses. Therefore, high doses of interleukin-2 (IL-2), a conventional cytokine for metastatic...

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Bibliografische gegevens
Hoofdauteurs: Park, Jason, Wrzesinski, Stephen H., Stern, Eric, Look, Michael, Criscione, Jason, Ragheb, Ragy, Jay, Steven M., Demento, Stacey L., Agawu, Atu, Limon, Paula Licona, Ferrandino, Anthony F., Gonzalez, David, Habermann, Ann, Flavell, Richard A., Fahmy, Tarek M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601683/
https://ncbi.nlm.nih.gov/pubmed/22797827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmat3355
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