Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy

The tumour microenvironment thwarts conventional immunotherapy through multiple immunologic mechanisms, such as the secretion of the transforming growth factor-β (TGF-β), which stunts local tumour immune responses. Therefore, high doses of interleukin-2 (IL-2), a conventional cytokine for metastatic...

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Bibliografiske detaljer
Main Authors: Park, Jason, Wrzesinski, Stephen H., Stern, Eric, Look, Michael, Criscione, Jason, Ragheb, Ragy, Jay, Steven M., Demento, Stacey L., Agawu, Atu, Limon, Paula Licona, Ferrandino, Anthony F., Gonzalez, David, Habermann, Ann, Flavell, Richard A., Fahmy, Tarek M.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601683/
https://ncbi.nlm.nih.gov/pubmed/22797827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmat3355
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