Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy

The tumour microenvironment thwarts conventional immunotherapy through multiple immunologic mechanisms, such as the secretion of the transforming growth factor-β (TGF-β), which stunts local tumour immune responses. Therefore, high doses of interleukin-2 (IL-2), a conventional cytokine for metastatic...

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Autors principals: Park, Jason, Wrzesinski, Stephen H., Stern, Eric, Look, Michael, Criscione, Jason, Ragheb, Ragy, Jay, Steven M., Demento, Stacey L., Agawu, Atu, Limon, Paula Licona, Ferrandino, Anthony F., Gonzalez, David, Habermann, Ann, Flavell, Richard A., Fahmy, Tarek M.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601683/
https://ncbi.nlm.nih.gov/pubmed/22797827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmat3355
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