The Antimalarial Natural Product Symplostatin 4 Is a Nanomolar Inhibitor of the Food Vacuole Falcipains

The marine natural product symplostatin 4 (Sym4) has been recognized as a potent antimalarial agent. However, its mode of action and, in particular, direct targets have to date remained elusive. We report a chemical synthesis of Sym4 and show that Sym4-treatment of P. falciparum-infected red blood c...

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Hauptverfasser: Stolze, Sara Christina, Deu, Edgar, Kaschani, Farnusch, Li, Nan, Florea, Bogdan I., Richau, Kerstin H., Colby, Tom, van der Hoorn, Renier A.L., Overkleeft, Hermen S., Bogyo, Matthew, Kaiser, Markus
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601557/
https://ncbi.nlm.nih.gov/pubmed/23261598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.09.020
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