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Vertical Integration of Pharmacogenetics in Population PK/PD Modeling: A Novel Information Theoretic Method
To critically evaluate an information-theoretic method for identifying gene–environmental interactions (GEI) associated with pharmacokinetic (PK), pharmacodynamic (PD), and clinical outcomes from genome-wide pharmacogenetic data. Our approach, which is built on the K-way interaction information (KWI...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3600754/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2012.25 |
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