Multiscale Kinetic Modeling of Liposomal Doxorubicin Delivery Quantifies the Role of Tumor and Drug-Specific Parameters in Local Delivery to Tumors

Nanoparticle encapsulation has been used as a means to manipulate the pharmacokinetic (PK) and safety profile of drugs in oncology. Using pegylated liposomal doxorubicin (PLD) vs. conventional doxorubicin as a model system, we developed and experimentally validated a multiscale computational model o...

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Detalhes bibliográficos
Main Authors: Hendriks, B S, Reynolds, J G, Klinz, S G, Geretti, E, Lee, H, Leonard, S C, Gaddy, D F, Espelin, C W, Nielsen, U B, Wickham, T J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600732/
https://ncbi.nlm.nih.gov/pubmed/23835797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2012.16
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