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The Arf6 GEF GEP100/BRAG2 Regulates Cell Adhesion by Controlling Endocytosis of β1 Integrins

The small GTPase Arf6 has been shown to regulate the post-endocytic trafficking of a subset of membrane proteins, including β1 integrins, and inhibition of Arf6 function impairs both cell adhesion and motility [1]. The activity of Arf GTPases is regulated by a large family of guanine nucleotide exch...

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Main Authors: Dunphy, Jillian L., Moravec, Radim, Ly, Kim, Lasell, Troy K., Melancon, Paul, Casanova, James E.
Format: Artigo
Jezik:Inglês
Izdano: 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600433/
https://ncbi.nlm.nih.gov/pubmed/16461286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2005.12.032
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