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Genome-Wide Detection of Single Nucleotide and Copy Number Variations of a Single Human Cell
Kindred cells can have different genomes because of dynamic changes in DNA. Single cell sequencing is needed to characterize these genomic differences but has been hindered by whole-genome amplification bias, resulting in low genome coverage. Here we report a new amplification method: Multiple Annea...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3600412/ https://ncbi.nlm.nih.gov/pubmed/23258894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1229164 |
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