Osbpl8 Deficiency in Mouse Causes an Elevation of High-Density Lipoproteins and Gender-Specific Alterations of Lipid Metabolism

OSBP-related protein 8 (ORP8) encoded by Osbpl8 is an endoplasmic reticulum sterol sensor implicated in cellular lipid metabolism. We generated an Osbpl8(−/−) (KO) C57Bl/6 mouse strain. Wild-type and Osbpl8KO animals at the age of 13-weeks were fed for 5 weeks either chow or high-fat diet, and their...

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Detalhes bibliográficos
Main Authors: Béaslas, Olivier, Metso, Jari, Nissilä, Eija, Laurila, Pirkka-Pekka, Kaiharju, Essi, Batchu, Krishna Chaithanya, Kaipiainen, Leena, Mäyränpää, Mikko I., Yan, Daoguang, Gylling, Helena, Jauhiainen, Matti, Olkkonen, Vesa M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3598917/
https://ncbi.nlm.nih.gov/pubmed/23554939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058856
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