Silencing of ANGPTL 3 (angiopoietin-like protein 3) in human hepatocytes results in decreased expression of gluconeogenic genes and reduced triacylglycerol-rich VLDL secretion upon insulin stimulation

Homozygosity of loss-of-function mutations in ANGPTL3 (angiopoietin-like protein 3)-gene results in FHBL2 (familial combined hypolipidaemia, OMIM #605019) characterized by the reduction of all major plasma lipoprotein classes, which includes VLDL (very-low-density lipoprotein), LDL (low-density lipo...

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Detalles Bibliográficos
Publicado en:Biosci Rep
Main Authors: Tikka, Anna, Soronen, Jarkko, Laurila, Pirkka-Pekka, Metso, Jari, Ehnholm, Christian, Jauhiainen, Matti
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2014
Assuntos:
Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266921/
https://ncbi.nlm.nih.gov/pubmed/25495645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20140115
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