Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential.

vav, a novel human oncogene, was originally generated in vitro by replacement of its normal 5' coding sequences with sequences from pSV2neo DNA, cotransfected as a selectable marker (S. Katzav, D. Martin-Zanca, and M. Barbacid, EMBO J. 8:2283-2290, 1989). The vav proto-oncogene is normally expressed...

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Publié dans:	Mol Cell Biol
Auteurs principaux:	Katzav, S, Cleveland, J L, Heslop, H E, Pulido, D
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 1991
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359873/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2005887/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.4.1912-1920.1991
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